Journal
IMMUNOLOGICAL INVESTIGATIONS
Volume 51, Issue 1, Pages 51-72Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/08820139.2020.1808672
Keywords
Brain; infarction; ischemia-reperfusion injury; microRNA; myocardium
Categories
Funding
- Shiraz Transplant Research Center, Shiraz University of Medical Sciences [95-01-15-12351]
Ask authors/readers for more resources
Heart and cerebral infarctions, two important ischemic diseases, could be improved by regulating miRNAs after ischemia reperfusion injury.
Heart and cerebral infarctions, as two important ischemic diseases, lead to the death of tissues due to inadequate blood supply and high mortality worldwide. These statuses are started via blockage of vessels and depletion of oxygen and nutrients which affected these areas. After reperfusion and restoration of oxygen supply, more severe injury was mediated by multifaceted cascades of inflammation and oxidative stress. microRNAs (miRNAs) as the regulator of biological and pathological pathways can adjust these conditions by interaction with their targets. Also, miRNAs can be modulated by preconditioning and external agents that may improve the functional outcome after IRI. miRNAs might be considered as therapeutic approaches to improve the symptoms of patients after myocardial infarction and cerebral ischemic stroke.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available