Journal
IEEE TRANSACTIONS ON NANOBIOSCIENCE
Volume 19, Issue 4, Pages 633-639Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TNB.2020.3014023
Keywords
Acute oral toxicity; Biogenic; Bryophyllum pinnatum; NTA; TEM; Zinc oxide nanoparticles
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The evaluation of toxic effects of nanoparticles (NPs) has become an important aspect of Nanotechnology research in the 21st century. The present investigation deals with the green synthesis of biogenic zinc oxide nanoparticles (ZnO-NPs) using Bryophyllum pinnatum leaves, their characterization and evaluation of acute oral toxicity in Wistar rats. The characterization of synthesized ZnO-NPs revealed maximum absorbance at 307 nm on UV-Vis spectrophotometric analysis, NTA showed mean size of particles and mode of the particles distribution as 128.2 nm and 12.6 nm, respectively. Zeta potential was found to be -0.369 mV. The absorbance shown by FTIR at 3469, 1644, 1355 and 887 cm(-1) indicates the involvement of biomolecules that are accountable for capping and stabilization of ZnO-NPs. The XRD assessment further demonstrated the crystalline nature of the ZnO-NP. The TEM analysis of the synthesized ZnO-NPs revealed the presence of spherical NPs with the mean size of 3.7 nm. The acute oral toxicity evaluation in rat showed an approximate median lethal dose to be more than 2000 mg/kg body weight. It is thus concluded that biogenic ZnO-NPs showed absence of acute oral toxicity symptoms at the doses employed in the present study.
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