Journal
IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS
Volume 14, Issue 5, Pages 1079-1087Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TBCAS.2020.3022839
Keywords
Wireless sensor networks; Wireless communication; Implants; Bluetooth; Field programmable gate arrays; Rodents; Clocks; Bioelectronics; neural interfacing; prosthetics; rodent
Funding
- Engineering and Physical Sciences Research Council (EPSRC), U.K. [EP/M025977/1, EP/N023080/1, EP/M020975/1, EP/R004242/1, EP/K015060/1]
- EPSRC [EP/M025977/1, EP/K015060/1, EP/N023080/1, EP/R004242/1] Funding Source: UKRI
- MRC [UKDRI-7004] Funding Source: UKRI
Ask authors/readers for more resources
Chronic in-vivo neurophysiology experiments require highly miniaturized, remotely powered multi-channel neural interfaces which are currently lacking in power or flexibility post implantation. In this article, to resolve this problem we present the SenseBack system, a post-implantation reprogrammable wireless 32-channel bidirectional neural interfacing that can enable chronic peripheral electrophysiology experiments in freely behaving small animals. The large number of channels for a peripheral neural interface, coupled with fully implantable hardware and complete software flexibility enable complex in-vivo studies where the system can adapt to evolving study needs as they arise. In complementary ex-vivo and in-vivo preparations, we demonstrate that this system can record neural signals and perform high-voltage, bipolar stimulation on any channel. In addition, we demonstrate transcutaneous power delivery and Bluetooth 5 data communication with a PC. The SenseBack system is capable of stimulation on any channel with +/- 20 V of compliance and up to 315 mu A of current, and highly configurable recording with per-channel adjustable gain and filtering with 8 sets of 10-bit ADCs to sample data at 20 kHz for each channel. To the best of our knowledge this is the first such implantable research platform offering this level of performance and flexibility post-implantation (including complete reprogramming even after encapsulation) for small animal electrophysiology. Here we present initial acute trials, demonstrations and progress towards a system that we expect to enable a wide range of electrophysiology experiments in freely behaving animals.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available