Journal
IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS
Volume 14, Issue 4, Pages 738-745Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TBCAS.2020.2995728
Keywords
Semiconductor lasers; Heating systems; Diode lasers; Biomedical optical imaging; Optical imaging; Laser diode; low-cost; multi-wavelength; nonlinear effect; photoacoustic imaging
Funding
- Natural Science Foundation of Shanghai [18ZR1425000]
- Natural Science Foundation of China [61805139]
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Photoacoustic imaging (PAI), an emerging imaging technique, exploits the merits of both optical and ultrasound imaging, equipped with optical contrast and deep penetration. Typical linear PAI relies on a nanosecond laser pulse to induce photoacoustic signals. To construct a multi-wavelength PAI system, a multi-wavelength nano-second laser source is required, which greatly increases the cost of the PAI system. However, according to the nonlinear photoacoustic effect, the amplitude of the photoacoustic signals will vary with different base temperatures of the tissue. Therefore, using continuous-wave lasers with different wavelengths to induce different temperature variations at the same point of the tissue, and then using a single-wavelength pulsed laser to induce photoacoustic signals has been an alternative method to achieve multi-wavelength PAI. In this paper, based on the nonlinear photoacoustic effect, we developed a continuous-wave multi-wavelength laser source to cut down the cost of the conventional multi-wavelength PAI system. The principle will be introduced firstly, followed by qualitative and quantitative experiments.
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