Journal
HEART LUNG AND CIRCULATION
Volume 30, Issue 2, Pages 186-196Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.hlc.2020.07.015
Keywords
Diabetes mellitus; Macrovascular complications; Atherosclerosis; Epigenetics
Categories
Funding
- National Natural Science Foundation of China [81770450, 81370408]
- Foundation of Jiangsu Province [WSN-04, LGY2018092, QNRC2016836]
Ask authors/readers for more resources
Diabetes mellitus is a metabolic disorder characterized by high blood sugar levels. Epigenetics has gained attention in exploring the causes and treatment of diabetes, with research showing that epigenetic regulation accelerates the development of macrovascular complications in diabetes.
Diabetes mellitus is a metabolic and endocrine disorder characterised by hyperglycaemia. Type 2 diabetes mellitus accounts for >90% of people with diabetes. Disorders of blood glucose metabolism and a series of adverse reactions triggered by hyperglycaemia-such as oxidative stress and inflammation-are conducive to the occurrence of diabetic macrovascular complications, which pose severe challenges to the quality of life and life expectancy of people with diabetes. In recent years, epigenetics has attracted more and more researchers' attention as they explore the causes and treatment of diabetes. Epigenetics refers to the regulation of gene expression without changes in gene content. Research focusses on DNA methylation, histone post translational modification and non-coding RNA. A series of studies have shown that epigenetic regulation accelerates the development of atherosclerosis by interfering with the physiological activities of macrophages, endothelial cells and smooth muscle cells, such as inflammation, lipid deposition and apoptosis. Therefore, it is particularly important to explore new epigenetic discoveries to reduce the severity and harmfulness of diabetes. This study reviewed recent advances in epigenetics in the pathogenesis of diabetes mellitus and its macrovascular complications.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available