Journal
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
Volume 42, Issue 12, Pages 3735-3743Publisher
WILEY
DOI: 10.1002/hed.26430
Keywords
autofluorescence; mouth neoplasms; precancerous conditions; tolonium chloride
Categories
Funding
- Korea Health Industry Development Institute [HI14C3228]
- National Research Foundation of Korea [2018M3A9E8020856, 2018R1D1A1B07045421, 2019M3A9H2032424, 2019M3E5D5064110]
- National Research Foundation of Korea [2019M3A9H2032424, 2018M3A9E8020856, 2019M3E5D5064110, 2018R1D1A1B07045421] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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The aim is to evaluate the accuracy of autofluorescence for screening oral cancer in comparison with toluidine blue staining and clinical examination. Oral mucosal disorders detected by autofluorescence were compared with those detected using toluidine blue staining. Methodological quality was evaluated using the Quality Assessment of Diagnostic Accuracy Studies tool. The diagnostic odds ratio (DOR) for autofluorescence was 8.197 (95% confidence interval, 4.018-16.723). The area under the summary receiver operating characteristic curve (AUC) was 0.815. Compared with toluidine blue, autofluorescence had a similar sensitivity, negative predictive value, and AUC but a lower specificity and DOR. Compared with clinical examination, the autofluorescence had a higher sensitivity but lower specificity, DOR, and AUC. Although the diagnostic accuracy of autofluorescence in the screening work-up of oral cancer and precancer was more sensitive than those of clinical examination and toluidine blue staining, it was not accurate enough to be used alone reliably.
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