Journal
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
Volume 43, Issue 2, Pages 473-484Publisher
WILEY
DOI: 10.1002/hed.26504
Keywords
betel quid chewing; cigarette smoking; oral; oropharyngeal cancer; survival; treatment delay
Categories
Funding
- Health Promotion Administration, Ministry of Health and Welfare of Taiwanese government [A1081113]
- Research Ethics Committee of National Taiwan University Hospital [201809041W]
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This study found that treatment delay longer than 6 weeks for oral/oropharyngeal cancer patients detected via a population-based screening program had unfavorable survival outcomes. Factors such as age, disease stage, and treatment facility type also influenced patient survival rates.
Background To assess the impact of treatment delay on survival of oral/oropharyngeal cancer (OSCC). Methods We followed 5743 OSCCs between 2004 and 2009 from a population-based screening program and ascertained death until the end of 2012. Results The hazard ratios (HRs) of mortality from OSCC were 1.46 (1.30-1.65) and 1.18 (1.04-1.33) in univariable and multivariable analyses, respectively, for treatment delay longer than 6 weeks compared with that shorter than 3 weeks. The corresponding figures were 1.12 (1.01-1.24) and 1.00 (0.91-1.11) for treatment delay between 3 and 6 weeks. Advancing age (1.01), higher stage (stage II: 1.84, stage III: 2.97, stage IV: 6.33), cancer in tongue (1.37), or hard palate (1.63) had higher HR of mortality (P < .05). However, treatment at medical center had a lower mortality (0.83, 0.75-0.91) than local/regional hospital. Conclusions Treatment delay longer than 6 weeks for OSCCs detected via a population-based screening program had unfavorable survival.
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