Journal
GYNECOLOGICAL ENDOCRINOLOGY
Volume 37, Issue 3, Pages 273-277Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/09513590.2020.1812567
Keywords
SPOCK2; endometrial epithelial cell; cell proliferation; adhesion; invasion
Funding
- National Natural Science Foundation of China [81501235]
Ask authors/readers for more resources
The downregulation of SPOCK2 was found to promote cell proliferation, adhesion, and invasion in human endometrial epithelial cells, suggesting its involvement in the pathogenesis and progression of endometriosis, as well as its malignant transformation.
Purpose A previous study found that a lack of SPOCK2 expression was an early event that occurs during the malignant transformation of endometriosis (EMS); however, the role played by SPOCK2 in the pathogenesis of endometriosis and its malignant transformation remains unclear. Materials and methods In this study, SPOCK2 expression in human endometrial epithelial cells (hEECs) was downregulated by transfection with shRNA, and the biological behavior of the transfected cells was observed. Results We found that downregulation of SPOCK2 promoted cell proliferation, adhesion, and invasion. Conclusions Our data suggest that downregulation of SPOCK2 might participate in the pathogenesis and progression of EMS, as well as its malignant transformation, by promoting the proliferation, adhesion, and invasion of endometrial epithelial cells.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available