Influence of vitrectomy on the progression of dry age-related macular degeneration

Purpose To demonstrate whether pars plana vitrectomy (PPV) changes the progression of dry age-related macular degeneration (AMD) by assessing longitudinal changes in drusen volume over follow-up. Methods Dry AMD patients who had undergone unilateral PPV for symptomatic vitreomacular disorders were evaluated for the progression of disease by spectral domain-optical coherence tomography (SD-OCT) features including drusen volume, development of geographic atrophy, or choroidal neovascularization during follow-up. Drusen volume was manually calculated using an image processing software (ImageJ, NIH) on raster SD-OCT scans. Mean change in drusen volume of surgery eyes was compared with values of the fellow eyes of the same subjects (control group). Results Among 183 eyes with both vitreoretinal disorder and dry AMD, 48 eyes of 24 patients met the inclusion criteria and were included. The mean drusen volume change during a mean of 25.49 +/- 23.35 months of follow-up (range: 6.00-86.87 months) was 4.236.899 +/- 20.488.913 mu m(3)in the study eye and 7.796.357 +/- 34.798.519 mu m(3)in the fellow eye (p= 0.297). Best-corrected visual acuity (BCVA) significantly increased from 0.40 +/- 0.18 logMAR (approximate to 20/50 Snellen equivalent) to 0.32 +/- 0.31 (approximate to 20/41 Snellen equivalent) after surgery (p= 0.012) in the study group while BCVA remained stable in the control group (0.19 +/- 0.34 logMAR [approximate to 20/30 Snellen equivalent] at baseline and 0.20 +/- 0.31 logMAR [approximate to 20/31 Snellen equivalent],p= 0.432). Choroidal neovascularization developed in 1 vitrectomized eye (4.54%) and in 1 eye (4.54%) from the control group during follow-up. Conclusion Vitrectomy did not seem to worsen dry AMD progression; even more visual acuity may improve despite a slight increase in drusen volume following surgery.

Automated summary

Longitudinal assessment of patients with dry AMD who underwent vitrectomy did not show exacerbated disease progression. Visual acuity improvement was observed in the study group despite a slight increase in drusen volume following surgery.