Journal
GENES CHROMOSOMES & CANCER
Volume 60, Issue 3, Pages 160-167Publisher
WILEY
DOI: 10.1002/gcc.22907
Keywords
chromosomal aberrations; endometrial stromal sarcoma; fusion gene; high‐ grade ESS; low‐ grade ESS
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Funding
- Anders Jahre's foundation through UNIFOR (University of Oslo)
- Norwegian Radium Hospital Foundation
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Endometrial stromal sarcomas (ESS) are a rare and heterogeneous group of mesenchymal cancers, now classified as low- or high-grade. They may have overlapping clinical presentation, morphology, and immunohistochemical profile. Understanding the molecular characteristics of ESS can improve diagnosis, prognostication, and treatment.
Endometrial stromal sarcomas (ESS) are a heterogeneous group of rare mesenchymal cancers. Considerable knowledge has been gained in recent years about the molecular characteristics of these cancers, which helps to classify them in a more meaningful manner leading to improved diagnosis, prognostication, and treatment. According to this classification, ESS is now grouped as low- or high-grade. ESS may have overlapping clinical presentation, morphology, and immunohistochemical profile. Their genetic characteristics allow subdivision of many of them depending on which pathogenetically important fusion genes they carry, but clearly much more needs to be unraveled in this regard. We here provide an overview of the molecular pathogenetic knowledge gained so far on low- and high-grade ESS.
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