4.6 Article

Association between polymorphisms in ABO gene and stroke patients with small artery occlusion in southern Chinese Han population

Journal

GENE
Volume 769, Issue -, Pages -

Publisher

ELSEVIER
DOI: 10.1016/j.gene.2020.145211

Keywords

Small artery occlusion stroke; ABO gene; Single nucleotide polymorphism; Ischemic stroke; Southern Chinese Han population

Funding

  1. Natural Science Foundation of Guangxi Province [2013GXNSFBA019131, 2015GXNSFAA139171, 2020GXNSFAA259053]
  2. Guangxi Scholarship Fund of Guangxi Education Department

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The study investigated the association between two SNPs in the ABO gene and the risk of small artery occlusion stroke in the southern Chinese Han population. The results showed that the rs532436 polymorphism was significantly associated with SAO, while the rs505922 polymorphism showed no significant association. This suggests a potential genetic influence on SAO in this population.
Objective: The purpose of this study was to investigate associations between two single nucleotide polymorphisms (SNPs) rs505922 and rs532436 in ABO gene and the risk of small artery occlusion stroke (SAO) in southern Chinese Han population. Methods: Our case-control study comprising 121 patients with SAO and 136 controls. All participants were Han population of southern China. IS sub-type was defined on the basis of the TOAST criteria. SAO was strictly diagnosed after a systematic physical examination and neuroimaging via MRI. Genotype analysis was conducted by the snapshot technique. Results: The distribution of rs532436 genotype between these two groups showed a statistically significant difference (P = 0.048) while that of rs505922 genotype showed no significant difference (P = 0.572). SNP rs532436 was significantly associated with SAO in overdominant model (GA vs. GG + AA) after adjusting for age, hypertension history, diabetes history and cigarette smoking (adjusted OR = 2.03, 95% CI: 1.14-3.62, P = 0.016). However, under all genetic models, the rs505922 polymorphism failed to show association with SAO. Conclusion: The results indicate that rs532436 polymorphism in ABO gene may have association with SAO in southern Chinese Han population.

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