Journal
FUTURE MICROBIOLOGY
Volume 15, Issue 11, Pages 1075-1090Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/fmb-2019-0343
Keywords
Candida albicans; histone acetyltransferases; histone deacetylases; potential antifungal targets; virulence
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Funding
- Beijing Health Alliance Charitable Foundation [WS630A]
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Recently, the incidence of invasive fungal infections has significantly increased.Candida albicans (C. albicans)is the most common opportunistic fungal pathogen that infects humans. The limited number of available antifungal agents and the emergence of drug resistance pose difficulties to treatment, thus new antifungals are urgently needed. Through their functions in DNA replication, DNA repair and transcription, histone acetyltransferases (HATs) and histone deacetylases (HDACs) perform essential functions relating to growth, virulence, drug resistance and stress responses ofC. albicans. Here, we summarize the physiological and pathological functions of HATs/HDACs, potential antifungal targets and underlying antifungal compounds that impact histone acetylation and deacetylation. We anticipate this review will stimulate the identification of new HAT/HDAC-related antifungal targets and antifungal agents.
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