Journal
FOOD CHEMISTRY
Volume 342, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2020.128338
Keywords
On-line separation; Chemiluminescence; Flavonoids; Total phenolic compounds; Microfluidic chip
Funding
- His Majesty Trust Funds [SR/SCI/CHEM/16/01]
- Sultan Qaboos University
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A microfluidic device was developed for simultaneous analysis of total flavonoids and total phenolic acids, utilizing magnetic ZIF-4 for separation and sensitive detection. The method showed high accuracy and recovery rates, proving successful in analyzing tea and honey samples.
A microfluidic device for simultaneous analysis of total flavonoids and total phenolic acids is presented for the first time. The process was based on the utilization of magnetic zinc-imidazole frameworks (ZIF-4), as a highly efficient media for on-line separation of phenolic acids and flavonoids, which were subsequently detected by a sensitive chemiluminescence (CL) method. Acrylate-based polymeric microchips containing a separation column (12.5 mm length, 3 mm width and 1 mm depth) were fabricated using a 3D-printer, and magnetic ZIF-4 was fixed into the column. The high porosity of the magnetic ZIF-4 made it a suitable adsorbent, guaranteeing an effective separation. The detection limits were in the range of 0.04-0.10 mu g mL(-1) with relative standard deviation values of (2.19-4.38%). The system was successfully applied for the analysis of flavonoids and phenolic acids in tea and honey samples. The recovery was from 95.4 to 104.1%, indicating a good accuracy of the developed method.
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