Journal
FITOTERAPIA
Volume 146, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.fitote.2020.104722
Keywords
1-Isoindolinone; Natural scaffolds; Anti-cancer drugs; Anti-bacterial agents; Anti-viral drug candidates; Medicinal chemistry
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Funding
- Midwest Veterans Biomedical Research Foundation (MVBRF), USA, KCVA Medical Center, Kansas City, MO
- National Institutes of Health/NIDDK [R01DK107490]
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Isoindolin-1-one or 1-isoindolinone framework is referred to phthalimidines or benzo fused gamma-lactams of the corresponding gamma-amino carboxylic acids and has been of prime interest for scientists for last several decades. 1-Isoindolinone framework is found in a wide range of naturally occurring compounds with diverse biological activities and therapeutic potential for various chronic diseases. Recent developments in synthetic methods for their procurement have opened a new era of 1-isoindolinone chemistry. This review aims to provide an alphabetical quick reference guide to only 1-isoindolinone based natural products and its variable fused, oxidized and reduced state skeleton with information for advanced chemotaxonomic analyses, cellular targets/pathways and diverse biological activities and future use for medicinal chemistry.
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