Journal
FITOTERAPIA
Volume 146, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.fitote.2020.104693
Keywords
Glycosmis pentaphylla; Rutaceae; Sulphur-containing amides; Anti-inflammatory property; Antiproliferative activity
Categories
Funding
- National Key Research and Development Program of China [2018YFC1708004]
- National Natural Science Foundation of China [81960762]
- Special Fund for Basic Scientific Research of Central Colleges, South-Central University for Nationalities [CZP18004, CZJ19001]
Ask authors/readers for more resources
Glycosmis pentaphylla (Retz.) DC (Rutaceae) has been traditionally considered as anti-cancer and anti-inflammatory medicine. However, active compounds of sulphur-containing amides remain largely unknown. In the present work, eighteen previously undescribed sulphur-containing amides (1-18) and three known analogues (19-21) were isolated from the leaves of G. pentaphylla. Their structures were elucidated by NMR spectroscopy and mass spectrometry. All isolated prenylated sulphur-containing amides were evaluated for their anti-inflammatory properties together with antiproliferative activities in vivo. Prenylated sulphur-containing amides exhibited significant inhibitory effects against nitric oxide (NO) production stimulated by lipopolysaccharide in mouse macrophage RAW 264.7 cells with the IC50 values ranging from 0.16 +/- 0.10 to 16.74 +/- 2.81 mu M. Meanwhile, sulphur-containing amides also exhibited considerable antiproliferative activities against HepG2 cell line with IC50 values ranging from 7.47 +/- 0.91 to 16.23 +/- 0.80 mu M. These findings enrich and improve the research on the structural diversity and biological activity of sulphur-containing amides and provide phytochemical and pharmacological evidence for the further development and utilization of the leaves of G. pentaphylla in pharmaceutical industry.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available