Journal
FITOTERAPIA
Volume 146, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.fitote.2020.104674
Keywords
Eupatorium chinense; Sesquiterpenoid; Benzofuran dimers; Structure elucidation; Cytotoxic activity
Categories
Funding
- National Natural Science Foundation of China [81803383]
- Master's Degree Dissertation Foundation of Three Gorges University in 2020 [2020SSPY145]
- Youth Science Foundation Project of China Three Gorges University [KJ2015A045]
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Three new sesquiterpenoids (1-3) and four new benzofuran dimers (+)-4 and (-)-4, (+)-5 and (-)-5, and four known benzofuran dimers (+)-6 and (-)-6, (+)-7 and (-)-7 were isolated from the underground parts of Eupatorium chinense. The enantiomers of racemates (+/-)-4 similar to (+/-)-7 were separated by chiral HPLC columns, and their absolute configurations were determined by circular dichroism experiments. The structures of all new compounds were elucidated on the basis of their NMR, and MS data as well as by comparison with literature values. The all of the isolated compounds were tested in vitro for their cytotoxic activities against the Caski, MDA-MB-231 and HepG2 cancer cell lines.
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