Journal
FEBS LETTERS
Volume 594, Issue 23, Pages 3920-3942Publisher
WILEY
DOI: 10.1002/1873-3468.13953
Keywords
ABC transporters; antibacterial peptides; bacteriocins; lantibiotics; mechanism; microcin; multidrug resistance; self-immunity; structure
Funding
- Deutsche Forschungsgemeinschaft (DFG) [Schm1279/13-1]
- DFG [417919780, INST 208/761-1 FUGG]
- Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) [270650915, GRK2158]
- Medical Research Council [MR/N020103/1]
- MRC [MR/N020103/1] Funding Source: UKRI
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Bacteria produce under certain stress conditions bacteriocins and microcins that display antibacterial activity against closely related species for survival. Bacteriocins and microcins exert their antibacterial activity by either disrupting the membrane or inhibiting essential intracellular processes of the bacterial target. To this end, they can lyse bacterial membranes and cause subsequent loss of their integrity or nutrients, or hijack membrane receptors for internalisation. Both bacteriocins and microcins are ribosomally synthesised and several are posttranslationally modified, whereas others are not. Such peptides are also toxic to the producer bacteria, which utilise immunity proteins or/and dedicated ATP-binding cassette (ABC) transporters to achieve self-immunity and peptide export. In this review, we discuss the structure and mechanism of self-protection that is conferred by these ABC transporters.
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