Journal
FEBS JOURNAL
Volume 288, Issue 7, Pages 2166-2183Publisher
WILEY
DOI: 10.1111/febs.15547
Keywords
apoptosis; caspase; CDPs; cell death; cell signaling; development; immunology; meeting; neuronal plasticity; nonapoptotic functions
Categories
Funding
- Batsheva de Rothschild Fund (under the Israel Academy of Sciences and Humanities)
- Chorafas Institute for Scientific Exchange (under the Weizmann Institute of Science)
- Aharon Katzir-Katchalsky Center
- Company of Biologists
- Moross Integrated Cancer Center at the Weizmann Institute
- Benoziyo Center for Neurological Diseases at the Weizmann Institute
- Deans of the Faculties of Biochemistry and Biology at the Weizmann Institute
- FEBS Journal
- Israel Science Foundation [1279/19]
- Minerva Foundation
- Federal German Ministry for Education and Research
- Estate of Emile Mimran
- European Union (RISE grant) [690939]
- Marie Curie Actions (MSCA) [690939] Funding Source: Marie Curie Actions (MSCA)
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Apoptosis is a major form of programmed cell death that plays a crucial role in maintaining tissue homeostasis and developmental processes. Research has unraveled the molecular details of the apoptosis program and the regulatory mechanisms of caspase activation. Moreover, recent studies suggest the essential role of apoptotic proteins in nonlethal cellular functions during normal development, tissue repair, and regeneration.
Apoptosis is a major form of programmed cell death (PCD) that eliminates unnecessary and potentially dangerous cells in all metazoan organisms, thus ensuring tissue homeostasis and many developmental processes. Accordingly, defects in the activation of the apoptotic pathway often pave the way to disease. After several decades of intensive research, the molecular details controlling the apoptosis program have largely been unraveled, as well as the regulatory mechanisms of caspase activation during apoptosis. Nevertheless, an ever-growing list of studies is suggesting the essential role of caspases and other apoptotic proteins in ensuring nonlethal cellular functions during normal development, tissue repair, and regeneration. Moreover, if deregulated, these novel nonapoptotic functions can also instigate diseases. The difficulty of identifying and manipulating thecaspase-dependent nonlethal cellularprocesses (CDPs), as well as thenonlethalfunctions of othercelldeathproteins (NLF-CDPs), meant that CDPs and NLF-CDPs have been only curiosities within the apoptotic field; however, the recent technical advancements and the latest biological findings are assigning an unanticipated biological significance to these nonapoptotic functions. Here, we summarize the various talks presented in the first international conference fully dedicated to discuss CDPs and NFL-CDPs and named 'The Batsheva de Rothschild Seminar on Non-Apoptotic Roles of Apoptotic Proteins'. The conference was organized between September 22, 2019, and 25, 2019, by Eli Arama (Weizmann Institute of Science), Luis Alberto Baena-Lopez (University of Oxford), and Howard O. Fearnhead (NUI Galway) at the Weizmann Institute of Science in Israel, and hosted a large international group of researchers.
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