Journal
FEBS JOURNAL
Volume 288, Issue 11, Pages 3334-3350Publisher
WILEY
DOI: 10.1111/febs.15589
Keywords
cell death; inflammation; innate immunity; NET formation; neutrophils
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Funding
- University of Dundee
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Cell death is a crucial part of infectious and sterile inflammatory reactions, with neutrophil extracellular traps (NETs) being a special form of lytic cell death. Recent research shows significant crosstalk between different cell death pathways, particularly apoptosis, pyroptosis, and necroptosis.
Cell death is an integral part of both infectious and sterile inflammatory reactions. Many cell death pathways cause the dying cell to lyse, thereby amplifying inflammation. A special form of lytic cell death is the formation of neutrophil extracellular traps (NETs), large structures of chromatin and antimicrobial proteins, which are released by dying neutrophils to capture extracellular pathogens and limit the spread of infections. The molecular mechanisms of NET formation remain incompletely understood. Recent research demonstrated substantial crosstalk between different cell death pathways, most notably between apoptosis, pyroptosis and necroptosis. Here, we review suicidal and vital NET formation and discuss potential crosstalk of their mechanisms of release with other forms of cell death.
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