Journal
EXPERIMENTAL GERONTOLOGY
Volume 138, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exger.2020.111005
Keywords
Cellular plasticity; Aging; Rejuvenation; Regeneration; Cellular senescence; Cellular reprogramming
Categories
Funding
- Institut Pasteur, Centre National pour la Recherche Scientifique
- Agence Nationale de la Recherche [ANR-10-LABX-73, ANR-16-CE13-0017-01]
- Fondation ARC [PJA 20161205028, 20181208231]
- AFM-Telethon Foundation
- Revive Consortium
- Agence Nationale de la Recherche (ANR) [ANR-16-CE13-0017] Funding Source: Agence Nationale de la Recherche (ANR)
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Aging is associated with diminished regenerative capacity and increased risk of chronic diseases. There is now compelling evidence suggests that aging process is reversible. Besides metabolic modification and systematic factors, both senescence elimination and cellular reprogramming showed beneficial effects on tissue regeneration and rejuvenation. Here we review recent studies on the interplay between cellular senescence and reprogramming. We discuss how both strategies could impact aging process and the possibility of combine them for more efficient regeneration and rejuvenation.
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