Journal
EXPERIMENTAL CELL RESEARCH
Volume 395, Issue 2, Pages -Publisher
ELSEVIER INC
DOI: 10.1016/j.yexcr.2020.112212
Keywords
FOXM1; Cyclin F; KIF20A; Ovarian cancer
Categories
Funding
- National Natural Science Foundation of China [81902650, 81672578, 81972437]
- China Postdoctoral Science Foundation [2019M662366]
- Program for Interdisciplinary Basic Research of Shandong University [2017JC040, 2018JC014]
- Key Research and Development Program of Shandong Province [2019GSF108122]
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Increased expression of FOXM1 is observed in a variety of human malignancies. The downstream target genes of FOXM1 involved in tumorigenesis and development are not fully elucidated in ovarian cancer. Here, we identified Cyclin F, a substrate recognition subunit of SCF (Skp1-Cul1-F-box protein) complex, and Kinesin Family Member 20A (KIF20A) were transcriptionally regulated by FOXM1 in ovarian cancer. Accordingly, Cyclin F and KIF20A were commonly overexpressed in ovarian cancer. Functionally, forced expression of Cyclin F or KIF20A significantly enhanced while knockdown of them decreased proliferation and invasion of ovarian cancer cells. Importantly, high levels of Cyclin F and KIF20A correlated with poor prognosis in patients with ovarian cancer. Our findings indicate that Cyclin F and KIF20A are functional targets of FOXM1 which might be potential drug targets in ovarian cancer.
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