A Role for Exercise to Counter Skeletal Muscle Clock Disruption

Disruption of the skeletal muscle circadian clock leads to a preferential shift toward lipid oxidation while reducing carbohydrate oxidation. These effects are apparent at the whole-body level, including glucose intolerance, increased energy expenditure, and fasting hyperglycemia. We hypothesize that exercise counters these metabolic disturbances by modifying the skeletal muscle clock and reverting substrate metabolism back toward an optimal substrate balance.

Automated summary

Disruption of the skeletal muscle circadian clock leads to a shift towards lipid oxidation and decrease in carbohydrate oxidation at the whole-body level, resulting in metabolic disturbances. Exercise is hypothesized to counter these disturbances by modifying the skeletal muscle clock and restoring optimal substrate balance.