Journal
EUROPEAN NEUROLOGY
Volume 83, Issue 5, Pages 536-541Publisher
KARGER
DOI: 10.1159/000510183
Keywords
History of medicine; Hyperosmolar therapy; Intracranial pressure; Hypertonic saline; Mannitol
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In this article, we commemorate the centenary of the discovery and clinical implementation of hyperosmolar therapy for the treatment of increased intracranial pressure (ICP). Following the pioneering work of anatomists Weed and McKibben in 1919, the use of hypertonic solutions was soon adopted into clinical practice, even though the preferred hypertonic agent, route of administration, and ideas regarding the physiological mechanism by which it reduced ICP diverged. These divergent conceptions and practices have continued to surround the use of hyperosmolar therapy into present times.
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