Journal
EUROPEAN JOURNAL OF PHARMACOLOGY
Volume 890, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.ejphar.2020.173617
Keywords
Emodin; Cardiovascular disease; Atherosclerosis; Therapeutic target
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Funding
- science and technology project of Huadu District of Guangzhou [18-HDWS-005]
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Emodin is a pharmacologically bioactive constituent isolated from the traditional Chinese medicinal herb Radix rhizoma Rhei, with antioxidant, anti-inflammatory, anti-proliferative, anti-apoptotic, and lipid-modulating effects. Experimental studies have shown that emodin can attenuate and stabilize atherosclerotic plaques, highlighting its therapeutic potential in patients with cardiovascular disease.
Atherosclerotic plaque formation, destabilization and eventual rupture leads to the acute cardiovascular events including myocardial infarction and stroke. Emodin (PubChem CID#3220), (1,3,8-trihydroxy-6-methylanthracene-9,10-dione) is a pharmacologically bioactive constituent isolated from the traditional Chinese medicinal herb Radix rhizoma Rhei. This molecule has anti-oxidant, anti-inflammatory, anti-proliferative, anti-apoptotic and lipid-modulating effects. Experimental studies have demonstrated that emodin attenuates and stabilizes atherosclerotic plaques. In this mini-review, we provide a summary of the pharmacological actions of emodin in regulating vascular function and atherosclerosis, highlighting the therapeutic potential of this phytochemical in patients with cardiovascular disease.
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