Journal
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
Volume 154, Issue -, Pages 297-308Publisher
ELSEVIER
DOI: 10.1016/j.ejpb.2020.07.017
Keywords
Lipid nanocapsules; Conjugated polymer nanoparticles; CN-PPV; PCPDTBT; Optical imaging; Photoacoustic imaging
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Funding
- Deutsche Forschungsgemeinschaft [391498659, RTG 2467]
- BMBF (Zentren fur Innovationskompetenz Program) [03Z22HN23]
- European Regional Development Funds for Saxony-Anhalt [EFRE: ZS/2016/04/78115]
- Martin Luther University Halle-Wittenberg
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Conjugated polymer nanoparticles (CPNs) have emerged as highly photostable probes for optical and photo-acoustic imaging. However, the aggregation of conjugated polymer (CP) molecules upon nanoparticle formation is associated with fluorescence quenching, poor yields and mutable particle sizes. This study investigated whether the CP encapsulation within the liquid midchain triglyceride (MCT) core of lipid nanocapsules (LNCs) may achieve reduced packing of CP chains leading to a stable system with enhanced optical features. The red-and near infrared-emitting CPs, CN-PPV and PCPDTBT, showed precipitation and aggregation-induced quenching with concentrations > similar to 25 mu g/mL in MCT alone. Despite this, CP encapsulation within LNCs abolished quenching at concentrations up to 1500 mu g/mL. PCPDTBT-LNCs exhibited a quantum yield of 2.8% and a higher signal:background ratio in an optical imaging phantom compared to literature reports of PCPDTBT encapsulated in PEG-PLGA nanoparticles. In contrast, PCPDTBT-LNCs had slightly lower photoacoustic amplitudes than reported PEG-PLGA systems. CP-LNCs were also stable in size (32 +/- 0.7 nm) and photoluminescence over 21 days at 4 degrees C, 25 degrees C and 37 degrees C. In summary, encapsulation of CP within the liquid core of lipid nanocapsules enhances the optical properties of fluorescent CP.
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