Journal
EUROPEAN JOURNAL OF PEDIATRICS
Volume 179, Issue 12, Pages 1963-1967Publisher
SPRINGER
DOI: 10.1007/s00431-020-03837-8
Keywords
GORD; GOR; Proton pump inhibitors; Infant reflux; H2 receptor antagonists
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Non-specific symptoms such as irritability, vomiting, and back arching during the infant period are often attributed to gastroesophageal reflux. While numerous studies have shown no significant benefit to the use of acid suppressant medications in this population, these medications are frequently prescribed in response to these symptoms. Our goals were to understand how often children were being prescribed this medication. To do this, data was extracted from a national database for reimbursement of prescribed medications through the General Medical Services scheme (GMS). Infants aged less than 1 year and eligible for reimbursement under GMS were included for analysis. A total of 450 infants per 10,000 eligible population received an anti-reflux preparation from the following drug classes (H2 antagonists, proton pump inhibitors, or alginate preparations) in 2018. This is compared with that in 2009 where only 137 per 10,000 eligible infants received these medications. This increase was predominantly attributable to an increase in ranitidine prescriptions. Conclusion: Despite a change in clinical guidelines, anti-reflux preparations are increasingly being prescribed to infants aged less than 1 year. The reasons behind the increase in prescriptions containing these medications cannot be ascertained from this data. This may suggest a proportion of these prescriptions may be unwarranted in this population. What is Known: The prescription of PPIs in infants has increased in a number of countries. Use of anti-reflux medications has a very poor evidence base in infancy. What is New: This data focuses only on an infant age group in a well cohort. Ranitidine may contribute to increased acid-suppressant use in infancy.
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