Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 204, Issue -, Pages -Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2020.112607
Keywords
Synthetic radical scavengers; Heterocycles; SAR Study; Antioxidants
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Funding
- Indian Council of Medical Research (ICMR), New Delhi [3/2/2/21/2019/NCD-III]
- DST PURSE Grant
- Jamia Hamdard [Deemed-to-be-University]
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In the present scenario, there has been a lot of consideration toward the field of free radical chemistry. Free radicals responsive oxygen species are produced by different endogenous frameworks, exposure to various physicochemical conditions, radiation, toxins, metabolized drug by-product, and pathological states. On the off chance that free radical overpowers the body's capacity, it generates a condition known as oxidative stress, which can alter physiological conditions of the body and results in several diseases. For appropriate physiological function, it is necessary to have a proper balance between free radicals and antioxidants. Antioxidants chemically inhibit the oxidation process; they are also known as free radical scavengers. For tackling the problem of oxidative stress application of an external source of antioxidant is helpful. A lot of antioxidants of natural, semi-synthetic and synthetic origin are in use, with time search of more effective, nontoxic, safe antioxidant is intensified. The present review, discuss different synthetic derivatives bearing various heterocyclic scaffolds as radical scavengers. (C) 2020 Elsevier Masson SAS. All rights reserved.
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