Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 202, Issue -, Pages -Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2020.112516
Keywords
Antitumour agents; bis(hydroxymethyl)pyrrolo[1,2-f]phenanthridine; Cell cycle; Cytotoxicity; DNA cross-Linking; Apoptosis
Categories
Funding
- Ministry of Science and Technology, Taiwan [MOST 107-2320-B-001-008, 108-2320-B001-002]
- Academia Sinica, Taipei, Taiwan [AS-100-TP-B13]
- National Research Program for Genomic Medicine (Taiwan)
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A series of 1,2-bis(hydroxymethyl)pyrrolo[1,2-f]phenanthridine derivatives and their alkyl (ethyl and isopropyl) carbamates and 12,13-bis(hydroxymethyl)-9,14-dihydro-dibenzo [f,h] pyrrolo [ 1,2-b]-blisoquinoline derivatives were synthesized for antiproliferative evaluation. The preliminary antitumour studies revealed that these two types of bis(hydroxymethyl) derivatives showed significant antitumour activities and were able to inhibit the growth of various human tumour cell lines in vitro. Several of the derivatives were demonstrated to cause DNA interstrand cross-links by an alkaline agarose gel shifting assay. These conjugates were cytotoxic to a variety of cancer cell lines by inducing DNA damage, delaying cell cycle progression in the G2/M phase and triggering apoptosis. Compound 21a, dissolved in a vehicle suitable for intravenous administration, was selected for antitumour studies in animal models. We demonstrated that at a dose that did not cause body weight loss in mice, compound 21a could significantly suppress the growth of tumour xenografts of human lung cancer H460 and colorectal cancer HCT-116 cells in nude mice. Our present results confirm the antitumour activities of these conjugates. (C) 2020 Elsevier Masson SAS. All rights reserved.
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