Journal
EUROPEAN JOURNAL OF IMMUNOLOGY
Volume 51, Issue 3, Pages 738-741Publisher
WILEY
DOI: 10.1002/eji.202048803
Keywords
CD28; Th1 cells; cytokine release; interferon gamma; Superagonistic antibody
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Funding
- FACS Core Unit of the IZKF Wurzburg
- DFG [BE4080/2-1, FOR2123, 210879364]
- DFG
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Research shows that mouse Th1 cells, similar to human Th1 cells, secrete IFN-gamma in response to stimulation with a superagonistic anti-CD28 monoclonal antibody. Crosslinking of the CD28-SA via FcR and CD40-CD40L interactions significantly enhances IFN-gamma release, highlighting the mouse as a useful model organism for studying immune responses in humans.
Like human Th1 cells, mouse Th1 cells also secrete IFN-gamma upon stimulation with a superagonistic anti-CD28 monoclonal antibody (CD28-SA). Crosslinking of the CD28-SA via FcR and CD40-CD40L interactions greatly increased IFN-gamma release. Our data stress the utility of the mouse as a model organism for immune responses in humans.
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