Journal
GUARDIANS OF THE GENOME: DNA DAMAGE AND REPAIR
Volume 64, Issue 5, Pages 847-862Publisher
PORTLAND PRESS LTD
DOI: 10.1042/EBC20200002
Keywords
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Funding
- UK Dementia Research Institute from UK DRI Ltd.
- UK Medical Research Council
- Alzheimer's Society
- Alzheimer's Research UK
- CHDI Foundation
- Evelyn Trust Grant
- Open Targets [OTAR2072]
- Cambridge Trust
- Masonic Charitable Foundation PhD Prize Studentship
- MRC [UKDRI-2006] Funding Source: UKRI
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Amyotrophic lateral sclerosis (ALS) is a rapidly disabling and fatal neurodegenerative disease. Due to insufficient disease-modifying treatments, there is an unmet and urgent need for elucidating disease mechanisms that occur early and represent common triggers in both familial and sporadic ALS. Emerging evidence suggests that impaired DNA damage response contributes to age-related somatic accumulation of genomic instability and can trigger or accelerate ALS pathological manifestations. In this review, we summarize and discuss recent studies indicating a direct link between DNA damage response and ALS. Further mechanistic understanding of the role genomic instability is playing in ALS disease pathophysiology will be critical for discovering new therapeutic avenues.
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