Journal
ENVIRONMENTAL POLLUTION
Volume 265, Issue PT A, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.envpol.2020.114855
Keywords
Cr(VI); Liver injury; Mitochondria dynamics disorder; AMPK/PGC-1 alpha; Division and fusion
Categories
Funding
- National Natural Science Foundation of China [31972754]
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Occupational exposure to hexavalent chromium (Cr(VI)) can cause cytotoxicity and carcinogenicity. In this study, we established a liver injury model in rats via intraperitoneal injection of potassium dichromate (0, 2, 4, and 6 mg/kg body weight) for 35 d to investigate the mechanism of Cr(VI)-induced liver injury. We found that Cr(VI) induced hepatic histopathological lesions, oxidative stress, and apoptosis and reduced the expression of mitochondrial-related regulatory factors such as adenosine 5'-monophosphate-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1 alpha) in a dose-dependent manner. Furthermore, Cr(VI) promoted mitochondrial division and inhibited fusion, leading to increased expression of caspase-3 and production of mitochondrial reactive oxygen species. Our study demonstrates that long-term exposure to Cr(VI) induces mitochondrial dynamics disorder by inhibiting AMPK/PGC-1 alpha signaling pathway in rat liver. (C) 2020 Elsevier Ltd. All rights reserved.
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