Journal
ENDOCRINE PATHOLOGY
Volume 31, Issue 4, Pages 330-336Publisher
HUMANA PRESS INC
DOI: 10.1007/s12022-020-09646-x
Keywords
Pituitary adenoma; Pituitary carcinoma; Pituitary neuroendocrine tumor; TPIT1; SF1; PIT1; Hormones; Immunohistochemistry; Biomarkers
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The traditional approach to the diagnosis of primary adenohypophyseal cell proliferations uses hormone immunohistochemistry to classify pituitary neuroendocrine tumors (PitNETs). The routine application of immunolocalization of pituitary transcription factors (SF1, PIT1, TPIT, ER alpha, and recently GATA3) along with adenohypophyseal hormones has taught us critical lessons that are discussed in this communication. We point out that appropriate patient care requires accurate diagnosis and is critical in the era of precision medicine. A misdiagnosis can result in far greater health care costs than the cost of accurate tumor classification and may have other unintended consequences. We provide additional insights about confusing findings in genomic studies, emphasizing that high-quality pathology is essential for strong science and translational research.
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