Journal
ELECTROPHORESIS
Volume 42, Issue 4, Pages 381-401Publisher
WILEY
DOI: 10.1002/elps.202000203
Keywords
Biomedical and clinical; Mass spectrometry; Metabolomics; microbial and plant; Technological developments
Funding
- Vidi grant scheme of the Netherlands Organization of Scientific Research [NWO Vidi 723.016.003]
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Capillary electrophoresis-mass spectrometry (CE-MS) has become a mature analytical technique in metabolomics, particularly for analyzing polar and charged metabolites efficiently. In recent years, there have been advancements in CE-MS methods and strategies for metabolomics, including improved interfacing techniques for coupling CE to MS, profiling metabolites in volume-restricted samples, and enhancing metabolic coverage.
Capillary electrophoresis-mass spectrometry (CE-MS) is now a mature analytical technique in metabolomics, notably for the efficient profiling of polar and charged metabolites. Over the past few years, (further) progress has been made in the design of improved interfacing techniques for coupling CE to MS; also, in the development of CE-MS approaches for profiling metabolites in volume-restricted samples, and in strategies that further enhance the metabolic coverage. In this article, which is a follow-up of a previous review article covering the years 2016-2018 (Electrophoresis2019, 40, 165-179), the main (technological) developments in CE-MS methods and strategies for metabolomics are discussed covering the literature from July 2018 to June 2020. Representative examples highlight the utility of CE-MS in the fields of biomedical, clinical, microbial, plant and food metabolomics. A complete overview of recent CE-MS-based metabolomics studies is given in a table, which provides information on sample type and pretreatment, capillary coatings, and MS detection mode. Finally, some general conclusions and perspectives are given.
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