Journal
ELECTROANALYSIS
Volume 33, Issue 1, Pages 216-225Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/elan.202060256
Keywords
3-Nitro-tyrosine; Oxidation; 3-Nitro-tyrosine-DNA interaction; Voltammetry; Agarose gel electrophoresis
Categories
Funding
- Fundacao de Amparo a Ciencia e Tecnologia do Estado de Pernambuco (FACEPE) [PPP/FACEPE/CNPq/APQ-0535-1.06/14]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [MCTI/CNPQ/Universal/APQ-422757/2018-7]
- FACEPE
- CAPES
Ask authors/readers for more resources
The electrochemical oxidation of 3-nitro-tyrosine at metallic electrodes was studied, revealing a complex process with strong interaction of 3-NO2-Tyr with dsDNA.
The electrochemical oxidation of 3-nitro-tyrosine (3-NO2-Tyr) was studied in aqueous media at metallic electrodes (platinum and gold), using voltammetric techniques. The interaction between 3-NO2-Tyr and double helix DNA (dsDNA) in a physiological medium was also investigated. Electro-oxidation of 3-NO2-Tyr occurs in one single irreversible pH-dependent step with the transfer of one electron and one proton from the phenolic group to the formation of radicals, which preferably dimerize, fouling the electrode surfaces. The differential pulse voltammetry and gel electrophoresis results clearly demonstrated a strong interaction of 3-NO2-Tyr with the dsDNA for the formation of a stable 3-NO2-Tyr-dsDNA complex.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available