Fabrication of Sensitive Membrane Electrodes and Their Application in Electrochemical Quantification of Ibandronate in Dosage Form

A new, highly selective, simple and accurate method was adopted and validated for the direct quantification of ibandronate sodium monohydrate (IBN) in tablets using sensitive polyvinyl chloride membrane electrodes. Three membranes were fabricated using dibutyl sebacate, nitrophenyl octyl ether and dioctyl phthalate. The fabricated electrodes showed fast response, capability of application in wide pH range and direct determination of IBN in turbid solutions. The most important advantage of the proposed analytical method is that it successfully allows direct determination of IBN in dosage form. The proposed analytical methodology can be applied for the direct quantification of IBN in pharmaceutical formulations.

Automated summary

A new analytical method using polyvinyl chloride membrane electrodes was developed for direct quantification of ibandronate sodium monohydrate (IBN) in tablets, showing fast response, wide pH range application, and capability to determine IBN in turbid solutions. This method allows for direct determination of IBN in dosage form and can be applied in pharmaceutical formulations.