Advances in the development of entry inhibitors for sialic-acid-targeting viruses

Over the past decades, several antiviral drugs have been developed to treat a range of infections. Yet the number of treatable viral infections is still limited, and resistance to current drug regimens is an ever-growing problem. Therefore, additional strategies are needed to provide a rapid cure for infected individuals. An interesting target for antiviral drugs is the process of viral attachment and entry into the cell. Although most viruses use distinct host receptors for attachment to the target cell, some viruses share receptors, of which sialic acids are a common example. This review aims to give an update on entry inhibitors for a range of sialic-acidtargeting viruses and provides insight into the prospects for those with broad-spectrum potential.

Automated summary

Despite the development of several antiviral drugs, the limited number of treatable viral infections and the growing problem of drug resistance have led researchers to explore additional strategies for rapid cure. Targeting the process of viral attachment and entry into the cell, particularly focusing on sialic-acid targeting viruses, provides insights into potential entry inhibitors with broad-spectrum potential.