Journal
DIABETOLOGIA
Volume 63, Issue 10, Pages 1981-1989Publisher
SPRINGER
DOI: 10.1007/s00125-020-05192-7
Keywords
Beta cell; Insulin biosynthesis; Insulin maturation; Post-transcriptional regulation; Proinsulin conversion; Review; Type 1 diabetes; Type 2 diabetes
Categories
Funding
- German-Israeli Foundation for Scientific Research and Development [I-1429-201.2/2017] Funding Source: Medline
- French National Agency for Research (ANR) and the German Research Foundation (DFG) [SO 818/6-1] Funding Source: Medline
- EU-IMI (INNODIA) [115797] Funding Source: Medline
- EU-IMI (RHAPSODY) [115881] Funding Source: Medline
- BMBF funded German Centre for Diabetes Research (DZD e.V.) [Institutional funding] Funding Source: Medline
Ask authors/readers for more resources
The discovery of insulin in 1921 has been one of greatest scientific achievements of the 20th century. Since then, the availability of insulin has shifted the focus of diabetes treatment from trying to keep patients alive to saving and improving the life of millions. Throughout this time, basic and clinical research has advanced our understanding of insulin synthesis and action, both in healthy and pathological conditions. Yet, multiple aspects of insulin production remain unknown. In this review, we focus on the most recent findings on insulin synthesis, highlighting their relevance in diabetes. Graphical abstract
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
