Journal
DEVELOPMENTAL BIOLOGY
Volume 469, Issue -, Pages 135-143Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ydbio.2020.10.006
Keywords
Drosophila melanogaster; Innate immunity; Blood cell; Hemocyte; Transdifferentiation
Categories
Funding
- National Research, Development and Innovation Office [GINOP-2.3.2-15-2016-00001, GINOP-2.3.2-15-2016-00035, OTKA K-131484]
- European Union
- State of Hungary
- European Social Fund [TAMOP 4.2.4.A/2-11-1-2012-0001]
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Transdifferentiation refers to the process of converting a differentiated cell type into another cell type without involving stem cells. Fruit flies are used as a model to study this process, particularly in the transition of plasmatocytes into lamellocytes. Researchers have utilized single-cell sequencing methods to cluster blood cells and better understand the mechanisms of transdifferentiation.
Transdifferentiation is a conversion of an already differentiated cell type into another cell type without the involvement of stem cells. This transition is well described in the case of vertebrate immune cells, as well as in Drosophila melanogaster, which therefore serves as a suitable model to study the process in detail. In the Drosophila larva, the latest single-cell sequencing methods enabled the clusterization of the phagocytic blood cells, the plasmatocytes, which are capable of transdifferentiation into encapsulating cells, the lamellocytes. Here we summarize the available data of the past years on the plasmatocyte-lamellocyte transition, and make an attempt to harmonize them with transcriptome-based blood cell clustering to better understand the underlying mechanisms of transdifferentiation in Drosophila, and in general.
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