Journal
DEVELOPMENT
Volume 147, Issue 16, Pages -Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.182725
Keywords
Developmental biology; Differentiation; circRNAs; Noncoding RNAs; Stem cells
Categories
Funding
- European Research Council [ERC-2019-SyG 855923-ASTRA]
- Fondazione Telethon [GGP16213]
- Associazione Italiana per la Ricerca sul Cancro [23053]
- Ministero dell'Istruzione, dell'Universita e della Ricerca [PRIN 2017 2017P352Z4]
- H2020 Marie Sklodowska-Curie Actions (H2020-MSCA-ITN-2016)
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In recent years, circular RNAs (circRNAs) - a novel class of RNA molecules characterized by their covalently closed circular structure have emerged as a complex family of eukaryotic transcripts with important biological features. Besides their peculiar structure, which makes them particularly stable molecules, they have attracted much interest because their expression is strongly tissue and cell specific. Moreover, many circRNAs are conserved across eukaryotes, localized in particular subcellular compartments, and can play disparate molecular functions. The discovery of circRNAs has therefore added not only another layer of gene expression regulation but also an additional degree of complexity to our understanding of the structure, function and evolution of eukaryotic genomes. In this Review, we summarize current knowledge of circRNAs and discuss the possible functions of circRNAs in cell differentiation and development.
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