4.5 Review

Perspective of Molecular Hydrogen in the Treatment of Sepsis

Journal

CURRENT PHARMACEUTICAL DESIGN
Volume 27, Issue 5, Pages 667-678

Publisher

BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1381612826666200909124936

Keywords

Sepsis; molecular hydrogen; organ injury; inflammation; oxidative stress; mechanisms

Funding

  1. Natural Science Foundation of Tianjin [17JCYBJC24800]
  2. Science and Technology Support Key Program [18YFZCSY00560]
  3. National Natural Science Foundation of China, Beijing, China [81772043, 81971879]

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Sepsis is a major cause of death in critically ill patients with no effective treatment, but molecular hydrogen shows potential therapeutic effects in sepsis. However, the specific treatment mechanism of molecular hydrogen remains unclear. Molecular hydrogen treatment can help improve organ injuries caused by sepsis.
Sepsis is the main cause of death in critically ill patients with no effective treatment. Sepsis is lifethreatening organ dysfunction due to a dysregulated host response to infection. As a novel medical gas, molecular hydrogen (H-2) has a therapeutic effect on many diseases, such as sepsis. H-2 treatment exerts multiple biological effects, which can effectively improve multiple organ injuries caused by sepsis. However, the underlying molecular mechanisms of hydrogen involved in the treatment of sepsis remain elusive, which are likely related to anti-inflammation, anti-oxidation, anti-apoptosis, regulation of autophagy and multiple signaling pathways. This review can help better understand the progress of hydrogen in the treatment of sepsis, and provide a theoretical basis for the clinical application of hydrogen therapy in sepsis in the future.

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