Applications of the Dess-Martin Oxidation in Total Synthesis of Natural Products

Dess-Martin periodinane (DMP), a commercially available chemical, is frequently utilized as a mild oxidative agent for the selective oxidation of primary and secondary alcohols to their corresponding aldehydes and ketones, respectively. DMP shows several merits over other common oxidative agents such as chromiumand DMSO-based oxidants; thus, it is habitually employed in the total synthesis of natural products. In this review, we try to underscore the applications of DMP as an effective oxidant in an appropriate step (steps) in the multi-step total synthesis of natural products.

Automated summary

Dess-Martin periodinane (DMP) is a commercially available chemical that is often utilized as a mild oxidative agent for the selective oxidation of alcohols to aldehydes and ketones. It has advantages over other common oxidative agents and is frequently employed in the total synthesis of natural products. This review emphasizes the applications of DMP as an effective oxidant in the multi-step total synthesis of natural products.