4.5 Review

Synthetic Routes to 2-Iminothiazolidines: State-of-the-Art 2006-2020

Journal

CURRENT ORGANIC CHEMISTRY
Volume 24, Issue 24, Pages 2823-2844

Publisher

BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1385272824999201019162400

Keywords

2-Iminothiazolidine; aziridine; thiirane; condensation; dominoring-opening cyclization; ring expansion

Funding

  1. CSIR, New Delhi, India [09/092(0665)/2008-EMR-I, 02-(0213)14/EMR-II]

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Multiheteroatom-containing small-sized cyclic molecules such as 2-iminothiazolidines are often found to possess beneficial pharmacological properties. In this review article, the biological significance of 2-iminothiazolidines is discussed and the literature reports published in the last 15 years spanning from 2006 to 2020 describing various preparative routes to access 2-iminothiazolidine derivatives have been categorically and chronologically described. The notable synthetic methods discussed here involve ring-expansion transformations of nonactivated and activated aziridines, thiiranes, epoxides, and other miscellaneous reactions.

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