4.5 Review

Synthesis and Anticancer Properties of 'Azole' Based Chemotherapeutics as Emerging Chemical Moieties: A Comprehensive Review

Related references

Note: Only part of the references are listed.
Article Chemistry, Applied

Synthesis of podophyllotoxin-glycosyl triazoles via click protocol mediated by silver (I)-N-heterocyclic carbenes and their anticancer evaluation as topoisomerase-II inhibitors

Srinivas Nerella et al.

Summary: This study reports the regioselective synthesis of podophyllotoxin-glycosyl triazole hybrids catalyzed by Ag(I)-NHC, showing promising anticancer activity against four human cancer cell lines. Compounds 5a and 5e were identified as potential leads due to their superior activity compared to the standard drug etoposide across all cell lines. Molecular docking studies revealed good agreement between the free energy calculations of active compounds and observed IC50 values.

NATURAL PRODUCT RESEARCH (2021)

Review Cell Biology

Targeting Aberrant RAS/RAF/MEK/ERK Signaling for Cancer Therapy

Ufuk Degirmenci et al.

CELLS (2020)

Review Cell Biology

Life, death, and autophagy in cancer: NF-κB turns up everywhere

Daniela Verzella et al.

CELL DEATH & DISEASE (2020)

Review Biochemistry & Molecular Biology

Recent Advances in the Chemical Synthesis and Evaluation of Anticancer Nucleoside Analogues

Mieke Guinan et al.

MOLECULES (2020)

Review Biochemistry & Molecular Biology

Plants derived therapeutic strategies targeting chronic respiratory diseases: Chemical and immunological perspective

Parteek Prasher et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2020)

Review Biochemistry & Molecular Biology

Application of triazoles as bioisosteres and linkers in the development of microtubule targeting agents

M. Shaheer Malik et al.

RSC MEDICINAL CHEMISTRY (2020)

Review Biochemistry & Molecular Biology

Advancement in the development of heterocyclic nucleosides for the treatment of cancer-A review

Agha Zeeshan Mirza

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS (2019)

Review Pharmacology & Pharmacy

The Azoles in Pharmacochemistry: Perspectives on the Synthesis of New Compounds and Chemoinformatic Contributions

Jessika de Oliveira Viana et al.

CURRENT PHARMACEUTICAL DESIGN (2019)

Article Chemistry, Medicinal

Cyclin-Dependent Kinase 2 Inhibitors in Cancer Therapy: An Update

Solomon Tadesse et al.

JOURNAL OF MEDICINAL CHEMISTRY (2019)

Review Biochemistry & Molecular Biology

Tailored therapeutics based on 1,2,3-1H-triazoles: a mini review

Parteek Prasher et al.

MEDCHEMCOMM (2019)

Review Oncology

The Use of Azoles Containing Natural Products in Cancer Prevention and Treatment: An Overview

Nasimudeen R. Jabir et al.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2018)

Review Oncology

Role of Azoles in Cancer Prevention and Treatment: Present and Future Perspectives

Khurshid Ahmad et al.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2018)

Article Biochemistry & Molecular Biology

NF-κB-mediated metabolic remodelling in the inflamed heart in acute viral myocarditis

Alexander H. V. Remels et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2018)

Article Chemistry, Medicinal

Synthesis and in vitro evaluations of 6-(hetero)-aryl-imidazo[1,2-b] pyridazine-3-sulfonamide's as an inhibitor of TNF-alpha production

Shivaji S. Pandit et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2018)

Review Medicine, Research & Experimental

Unleashing endogenous TNF-alpha as a cancer immunotherapeutic

Steven F. Josephs et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2018)

Review Endocrinology & Metabolism

The Role of the Transcription Factor Nuclear Factor-kappa B in Thyroid Autoimmunity and Cancer

Cesidio Giuliani et al.

FRONTIERS IN ENDOCRINOLOGY (2018)

Review Pharmacology & Pharmacy

Recent developments in topoisomerase-targeted cancer chemotherapy

Kirk E. Hevener et al.

ACTA PHARMACEUTICA SINICA B (2018)

Article Multidisciplinary Sciences

In situ click chemistry generation of cyclooxygenase-2 inhibitors

Atul Bhardwaj et al.

NATURE COMMUNICATIONS (2017)

Review Pharmacology & Pharmacy

The 1,2,3-triazole ring as a bioisostere in medicinal chemistry

Elisa Bonandi et al.

DRUG DISCOVERY TODAY (2017)

Review Biochemistry & Molecular Biology

Medicinal attributes of 1,2,3-triazoles: Current developments

Divya Dheer et al.

BIOORGANIC CHEMISTRY (2017)

Article Chemistry, Medicinal

Exploration of SAR for novel 2-benzylbenzimidazole analogs as inhibitor of transcription factor NF-κB

PullaReddy Boggu et al.

ARCHIVES OF PHARMACAL RESEARCH (2017)

Review Oncology

Recent Developments on 1,2,4-Triazole Nucleus in Anticancer Compounds: A Review

Ramandeep Kaur et al.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2016)

Article Biochemistry & Molecular Biology

Exploration of 2-benzylbenzimidazole scaffold as novel inhibitor of NF-κB

PullaReddy Boggu et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2016)

Review Chemistry, Medicinal

Compounds Containing Azole Scaffolds as Cyclooxygenase Inhibitors: A Review

Hanan M. A. Ragab et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2016)

Article Chemistry, Medicinal

1,2,3-Triazoles as Amide Bioisosteres: Discovery of a New Class of Potent HIV-1 Vif Antagonists

Idrees Mohammed et al.

JOURNAL OF MEDICINAL CHEMISTRY (2016)

Article Chemistry, Organic

Antiproliferative activity of bicyclic benzimidazole nucleosides: synthesis, DNA-binding and cell cycle analysis

Vyankat A. Sontakke et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2016)

Article Oncology

The role of osteoclasts in breast cancer bone metastasis

Francois Le Pape et al.

JOURNAL OF BONE ONCOLOGY (2016)

Review Toxicology

NF-κB in cancer therapy

Feng Li et al.

ARCHIVES OF TOXICOLOGY (2015)

Article Chemistry, Multidisciplinary

New insights into the kinetic target-guided synthesis of protein ligands

Emilia Oueis et al.

CHEMICAL COMMUNICATIONS (2015)

Article Biochemistry & Molecular Biology

Identification of an indole-triazole-amino acid conjugate as a highly effective antifungal agent

Kalpana Pawar et al.

MEDCHEMCOMM (2015)

Review Biochemistry & Molecular Biology

Inhibition of Topoisomerase (DNA) I (TOP1): DNA Damage Repair and Anticancer Therapy

Yang Xu et al.

BIOMOLECULES (2015)

Article Chemistry, Medicinal

Syntheses and structure-activity relationships for some triazolyl p38α MAPK inhibitors

Jean-Paul G. Seerden et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2014)

Review Biochemistry & Molecular Biology

TNF and TNF-receptors: From mediators of cell death and inflammation to therapeutic giants - past, present and future

Lisa M. Sedger et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2014)

Article Oncology

NF-κB, an Active Player in Human Cancers

Yifeng Xia et al.

CANCER IMMUNOLOGY RESEARCH (2014)

Article Chemistry, Multidisciplinary

1,2,3-Triazoles as Amide Bond Mimics: Triazole Scan Yields Protease-Resistant Peptidomimetics for Tumor Targeting

Ibai E. Valverde et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2013)

Article Chemistry, Multidisciplinary

2-Amino-1,3-thiazoles Suppressed Lipopolysaccharide-Induced IL-β and TNF-α

Kee Dal Nam et al.

BULLETIN OF THE KOREAN CHEMICAL SOCIETY (2013)

Review Biochemistry & Molecular Biology

The complexity of NF-κB signaling in inflammation and cancer

Bastian Hoesel et al.

MOLECULAR CANCER (2013)

Review Oncology

Targeting nuclear factor-kappa B to overcome resistance to chemotherapy

P. Godwin et al.

FRONTIERS IN ONCOLOGY (2013)

Review Oncology

Topoisomerase I inhibition in colorectal cancer: biomarkers and therapeutic targets

D. C. Gilbert et al.

BRITISH JOURNAL OF CANCER (2012)

Review Pharmacology & Pharmacy

Targeting the MAPK-RAS-RAF signaling pathway in cancer therapy

Libero Santarpia et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2012)

Article Chemistry, Multidisciplinary

Melting Thermodynamics of Reversible DNA/Ligand Complexes at Interfaces

Irina Belozerova et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)

Review Oncology

Bone metastasis in breast cancer: The story of RANK-Ligand

Hamdy A. Azim et al.

JOURNAL OF THE EGYPTIAN NATIONAL CANCER INSTITUTE (2012)

Review Chemistry, Multidisciplinary

Click Chemistry: 1,2,3-Triazoles as Pharmacophores

Sandip G. Agalave et al.

CHEMISTRY-AN ASIAN JOURNAL (2011)

Article Biochemistry & Molecular Biology

Pharmacological significance of triazole scaffold

Rajeev Kharb et al.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2011)

Review Biochemistry & Molecular Biology

NF-κB addiction and its role in cancer: 'one size does not fit all'

M. M. Chaturvedi et al.

ONCOGENE (2011)

Article Multidisciplinary Sciences

TNF-α Contributes to Caspase-3 Independent Apoptosis in Neuroblastoma Cells: Role of NFAT

Susana Alvarez et al.

PLOS ONE (2011)

Article Chemistry, Medicinal

Identification of benzimidazole-based inhibitors of the mitogen activated kinase-5 signaling pathway

Patrick T. Flaherty et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)

Article Chemistry, Medicinal

Synthesis and antitumor activity of novel 2',3'-dideoxy-2',3'-diethane thionucleosides bearing 1,2,3-triazole residues

Jin-Lan Yu et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)

Review Chemistry, Multidisciplinary

Kinetic target-guided synthesis

Xiangdong Hu et al.

CHEMICAL SOCIETY REVIEWS (2010)

Review Chemistry, Multidisciplinary

In situ click chemistry: probing the binding landscapes of biological molecules

Sreeman K. Mamidyala et al.

CHEMICAL SOCIETY REVIEWS (2010)

Article Chemistry, Medicinal

Solvent free synthesis of 1,5-disubstituted tetrazoles derived from Baylis Hillman acetates as potential TNF-α inhibitors

P. Srihari et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)

Review Oncology

Targeting DNA topoisomerase II in cancer chemotherapy

John L. Nitiss

NATURE REVIEWS CANCER (2009)

Review Oncology

Tumour necrosis factor and cancer

Frances Balkwill

NATURE REVIEWS CANCER (2009)

Review Chemistry, Medicinal

Prodrugs of nucleoside analogues for improved oral absorption and tissue targeting

Fujun Li et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2008)

Review Biochemistry & Molecular Biology

Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance

James A. McCubrey et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2007)

Review Biochemistry & Molecular Biology

P38 MAP-Kinases pathway regulation, function and role in human diseases

Ana Cuenda et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2007)

Review Biochemistry & Molecular Biology

Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer

P. J. Roberts et al.

ONCOGENE (2007)

Review Biochemistry & Molecular Biology

MAP kinase signalling pathways in cancer

A. S. Dhillon et al.

ONCOGENE (2007)

Article Chemistry, Organic

1,2,3-Triazoles as peptide bond isosteres: synthesis and biological evaluation of cyclotetrapeptide mimics

Victoria D. Bock et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2007)

Review Pharmacology & Pharmacy

Nucleoside analogue delivery systems in cancer therapy

Roudayna Diab et al.

EXPERT OPINION ON DRUG DELIVERY (2007)

Review Pharmacology & Pharmacy

In situ click chemistry: a powerful means for lead discovery

K. Barry Sharpless et al.

EXPERT OPINION ON DRUG DISCOVERY (2006)

Review Biochemistry & Molecular Biology

Mutations in the NF-κB signaling pathway:: implications for human disease

G. Courtois et al.

ONCOGENE (2006)

Review Pathology

NF-kB in development and progression of human cancer

X Dolcet et al.

VIRCHOWS ARCHIV (2005)

Review Biochemistry & Molecular Biology

Cyclins and cdks in development and cancer: a perspective

A Deshpande et al.

ONCOGENE (2005)

Article Chemistry, Multidisciplinary

In situ click chemistry: Enzyme-generated inhibitors of carbonic anhydrase II

VP Mocharla et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2005)

Article Biochemistry & Molecular Biology

Tumor necrosis factor alpha-induced apoptosis requires p73 and c-ABL activation downstream of RB degradation

BN Chau et al.

MOLECULAR AND CELLULAR BIOLOGY (2004)

Article Chemistry, Multidisciplinary

In situ click chemistry: Enzyme inhibitors made to their own specifications

R Manetsch et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2004)

Review Biochemistry & Molecular Biology

Tumor necrosis factor signaling

H Wajant et al.

CELL DEATH AND DIFFERENTIATION (2003)

Review Oncology

Nucleoside analogues and nucleobases in cancer treatment

CM Galmarini et al.

LANCET ONCOLOGY (2002)