Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 64, Issue -, Pages 66-71Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2020.05.033
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Funding
- Herchel Smith Fellowship in Science
- Swedish Research Council [2017-06278]
- Wellcome
- Bloodwise
- MRC
- CRUK
- MRC [MR/S036113/1, MC_PC_17230] Funding Source: UKRI
- Swedish Research Council [2017-06278] Funding Source: Swedish Research Council
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Major developmental processes such as gastrulation and early embryogenesis rely on a complex network of cell-cell interactions, chromatin remodeling, and transcriptional regulators. This makes it challenging to study early development when using bulk populations of cells. Recent advances in single-cell technologies have allowed researchers to better understand the interactions between different molecular modalities and the heterogeneities within classically defined cell types. As new single-cell technologies mature, they have the potential of providing a step-change in our understanding of embryogenesis. In this review, we summarize recent advances in single-cell technologies with particular focus on those that lend insight into early organogenesis. We then discuss current pitfalls and implications for future research.
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