Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 65, Issue -, Pages 141-149Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2020.06.004
Keywords
Clathrin; Clathrin-mediated endocytosis; Membrane traffic; Clathrin-actin interaction; Clathrin-microtubule interaction
Categories
Funding
- Wellcome Trust Investigator Award [107858/Z/15/Z]
- MRC-UKRI grant [MR/S008144/1]
- Wellcome Trust [107858/Z/15/Z] Funding Source: Wellcome Trust
- MRC [MR/S008144/1] Funding Source: UKRI
Ask authors/readers for more resources
Understanding of the range and mechanisms of clathrin functions has developed exponentially since clathrin's discovery in 1975. Here, newly established molecular mechanisms that regulate clathrin activity and connect clathrin pathways to differentiation, disease and physiological processes such as glucose metabolism are reviewed. Diversity and commonalities of clathrin pathways across the tree of life reveal speciesspecific differences enabling functional plasticity in both membrane traffic and cytokinesis. New structural information on clathrin coat formation and cargo interactions emphasises the interplay between clathrin, adaptor proteins, lipids and cargo, and how this interplay regulates quality control of clathrin's function and is compromised in infection and neurological disease. Roles for balancing clathrin-mediated cargo transport are defined in stem cell development and additional disease states.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available