Journal
CURRENT OPINION IN BIOTECHNOLOGY
Volume 65, Issue -, Pages 205-212Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2020.04.002
Keywords
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Funding
- National Natural Science Foundation of China [31720103901]
- '111' Project of China [B18022]
- Fundamental Research Funds for the Central Universities [22221818014S]
- State Key Laboratory of Bioreactor Engineering
- Shandong Taishan Scholar Award
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Industrial biosynthesis is a very complex process which depends on a range of different factors, from intracellular genes and metabolites, to extracellular culturing conditions and bioreactor engineering. The identification of species that improve the titer of some reaction is akin to the task of finding a needle in a haystack. This review aims to summarize state-of-the-art biosynthesis titer improvement on different scales separately, particularly regarding the advancement of metabolic pathway rewiring and data-driven process optimization and control. By integrating multi-scale data and establishing a mathematical replica of a real biosynthesis, more refined quantitative insights can be gained for achieving a higher titer than ever.
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