Journal
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
Volume 55, Issue 6, Pages 509-524Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10409238.2020.1818684
Keywords
Mitochondrion; DNA replication; deletion; DNA helicase; DNA polymerase
Categories
Funding
- Swedish Research Council [2018-02439, 2017-01257]
- Swedish Cancer Foundation [2019-816, 2017-631]
- Knut and Alice Wallenberg Foundation [KAW 2017.0080]
- European Research Council [683191]
- Swedish Government [ALFGBG-727491, ALFGBG-728151]
- Swedish County Councils, the ALF [ALFGBG-727491, ALFGBG-728151]
- Swedish Research Council [2017-01257, 2018-02439] Funding Source: Swedish Research Council
- Formas [2018-02439] Funding Source: Formas
- European Research Council (ERC) [683191] Funding Source: European Research Council (ERC)
Ask authors/readers for more resources
Mammalian mitochondria contain multiple copies of a circular, double-stranded DNA genome (mtDNA) that codes for subunits of the oxidative phosphorylation machinery. Mutations in mtDNA cause a number of rare, human disorders and are also associated with more common conditions, such as neurodegeneration and biological aging. In this review, we discuss our current understanding of mtDNA replication in mammalian cells and how this process is regulated. We also discuss how deletions can be formed during mtDNA replication.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
