Journal
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
Volume 55, Issue 5, Pages 469-481Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10409238.2020.1811630
Keywords
DNA replication; replisome; DNA polymerase; polymerase delta; replication fork
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Funding
- Medical Research Council as part of United Kingdom Research and Innovation [MRC] [MC_UP_1201/12]
- Sir Henry Wellcome Postdoctoral Fellowship from the Wellcome Trust [213596/Z/18/Z]
- MRC [MC_UP_1201/12] Funding Source: UKRI
- Wellcome Trust [213596/Z/18/Z] Funding Source: Wellcome Trust
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In eukaryotes three DNA polymerases (Pols), alpha, delta, and epsilon, are tasked with bulk DNA synthesis of nascent strands during genome duplication. Most evidence supports a model where Pol alpha initiates DNA synthesis before Pol epsilon and Pol delta replicate the leading and lagging strands, respectively. However, a number of recent reports, enabled by advances in biochemical and genetic techniques, have highlighted emerging roles for Pol delta in all stages of leading-strand synthesis; initiation, elongation, and termination, as well as fork restart. By focusing on these studies, this review provides an updated perspective on the division of labor between the replicative polymerases during DNA replication.
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