4.6 Review

State-of-the-Art on Functional Titanium Dioxide-Integrated Nano-Hybrids in Electrical Biosensors

Journal

CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
Volume 52, Issue 3, Pages 637-648

Publisher

TAYLOR & FRANCIS INC
DOI: 10.1080/10408347.2020.1816447

Keywords

Electrochemical biosensor; electronic transducer; nanocomposite; organic-inorganic materials; quantitative biosensor

Funding

  1. HICOE (Phase II) fund-MEMS for Biomedical Devices (Artificial Kidney) from Ministry of Education [AKU254]
  2. Modal Insan Fund [MI-2019-005]
  3. Universiti Kebangsaan Malaysia (UKM) [DIP-2018-006]

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Biosensors based on electrical methods are advancing towards rapid and efficient detection, with nano-hybrid technologies improving detection strategies. Titanium dioxide nanomaterials have shown promising results as electrical transducing materials in biosensor construction, enhancing stability, reproducibility, and sensitivity. This review highlights recent advancements and successful stories of functional TiO2 nano-hybrid materials in electrical biosensors, as well as discussing future research directions and commercialization prospects.
Biosensors operating based on electrical methods are being accelerated toward rapid and efficient detection that improve the performance of the device. Continuous study in nano- and material-sciences has led to the inflection with properties of nanomaterials that fit the trend parallel to the biosensor evolution. Advancements in technology that focuses on nano-hybrid are being used to develop biosensors with better detection strategies. In this sense, titanium dioxide (TiO2) nanomaterials have attracted extensive interest in the construction of electrical biosensors. The formation of TiO(2)nano-hybrid as an electrical transducing material has revealed good results with high performance. The modification of the sensing portion with a combination (nano-hybrid form) of nanomaterials has produced excellent sensors in terms of stability, reproducibility, and enhanced sensitivity. This review highlights recent research advancements with functional TiO(2)nano-hybrid materials, and their victorious story in the construction of electrical biosensors are discussed. Future research directions with commercialization of these devices and their extensive utilizations are also discussed.

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