Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 194, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.colsurfb.2020.111178
Keywords
Silver nanoparticles; Magnetic nanoparticles; Antibacterial; Hyperthermia
Funding
- Spanish Ministry of Economy and Competitiveness [SAF2017-87305-R, MAT2015-71806-R]
- Madrid Regional Government [NANOMAGCOST-CM P2018/NMT-4321]
- European Commission's H2020 program (NoCanTher project) [685795]
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The antibacterial activity of hybrid gamma-Fe2O3/Ag nanocomposites against the bacterial pathogens E. coli (Gramnegative) and S. aureus (Gram-positive) has been studied. Silver is a well-known bactericidal agent and gamma-Fe2O3 nanoparticles release heat when they are exposed to alternating magnetic fields. The combination of both properties to fight infections has not been previously explored. The nanocomposites were synthesized through reduction of silver nitrate in the presence of pre-synthesized superparamagnetic gamma-Fe2O3 nanoparticles. Changing systematically the ratio of gamma-Fe2O3 and silver precursor and the temperature of the reaction allowed obtaining superparamagnetic nanocomposites with different Ag contents and particle sizes. The antibacterial activity of the samples was tested, and the minimum inhibitory concentrations and minimum bactericidal concentrations of the nanocomposites were determined to compare the microbicidal activity of the samples. It was found that it is related with the release of silver ions from the nanocomposites. Finally, we studied the combination of the bactericidal effect of silver and magnetic hyperthermia finding a synergetic effect between them when plates containing E. coli or S. aureus bacteria with gamma-Fe2O3/Ag nanocomposites were subjected to an alternating magnetic field. This effect is related with an increase in the release of silver ions due to that heat dissipation.
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